PIC stands for Polymorphic Information Content, which is a measure used to quantify the informativeness or utility of a genetic marker system. It assesses the discriminatory power of a marker system by measuring the level of polymorphism or genetic variation detected among individuals or populations.

The significance of PIC for a marker system lies in its ability to:

·        Reflect Genetic Diversity: PIC provides insight into the level of genetic diversity present within a population or among different populations. A marker system with high PIC values indicates a high degree of polymorphism, suggesting greater genetic variability.

·        Informative Marker Selection: PIC helps in the selection of informative markers for genetic studies, breeding programs, and population genetics analyses. Markers with high PIC values are preferred because they have a greater ability to differentiate between genotypes and provide more robust information for genetic analysis.

·        Marker Suitability: PIC aids in evaluating the suitability of a marker system for specific applications. For example, in linkage mapping and association studies, markers with high PIC values are preferred as they are more likely to be informative for detecting genetic linkage or associations with phenotypic traits.

·        Marker Comparisons: PIC allows for the comparison of different marker systems or assays in terms of their informativeness and discriminatory power. By comparing PIC values, researchers can identify the most suitable marker system for their research objectives and experimental conditions.

·        Population Genetics Studies: In population genetics studies, PIC is used to assess the genetic structure and diversity of populations. High PIC values indicate a greater level of genetic differentiation among populations, while low PIC values suggest genetic similarity or admixture.

·        Breeding Program Applications: In breeding programs, markers with high PIC values are valuable for marker-assisted selection (MAS) and genomic selection. They facilitate the identification of genetic variants associated with target traits and aid in the development of improved cultivars with desirable traits.

Overall, PIC serves as a useful metric for evaluating the effectiveness and utility of a marker system in capturing genetic variation and providing informative data for genetic analysis and applications. It helps researchers make informed decisions regarding marker selection, experimental design, and data interpretation in various genetic studies and breeding programs.